Nineteen of Medvedev's 21 victories have been earned on hard surfaces
A resurgent the Russian player won his initial championship for 882 days with a win over Corentin Moutet in the tournament final.
Medvedev, a ex- world number one, has had a challenging year, winning just one win at the big events and experiencing a meltdown at the US Open.
The player's unpredictability on the ATP Tour - and issues with his service game in specific - led to him dropping out of the world's top 10 and eventually parting ways with long-time trainer his previous coach.
Currently training with Thomas Johansson and Rohan Goetzke, he has consistently improved in the past month - peaking in a hard-fought 7-5 4-6 6-3 triumph over Frenchman Corentin Moutet.
It is the player's maiden trophy since the Italian tournament and initial on a hardcourt since that period of the previous year.
The win also means Medvedev has achieved 21 championships at 21 distinct events.
"It's the first time I am participating in a event with my both daughters at once, so to get a championship is especially meaningful," said world number 14 Daniil Medvedev.
"This title is in dedication of my second daughter my daughter, because the initial championship I got when my child Alisa was born was for her."
The tennis star, the 2021 US Open champion, had lost his previous six finals, comprising in Halle previously this season.
Medvedev's counter-punching strategy and recurring reactions on the playing surface had prompted observers to wonder if his skill to perform at the top level was finished.
Yet the athlete has made changes in the past month, making an effort to advance forward and play positively, supported by an better serving game.
He recovered from a break down in the initial set against the difficult opponent, taking 4 of the last five points to gain the advantage.
Both players traded break points in the second set before the Frenchman, striving for his maiden ATP Tour title, seized the initiative to create a final set.
The opponent saved 4 early opportunities in a competitive third set before Medvedev secured a break to 15 to secure the win.
Appropriately, the winner earned victory with a shot at the net, with Moutet unable to manage a shot after over two and a half hours.